HepaHope Company History

• 1999  –  Foundation of HepaHope Inc. in Silicon Valley, USA
• 2000  –  Foundation of HepaHope Korea
• 2001  – First demonstration of “Proof of Concept” studies indicating that HepaHope
  bio-artificial liver performs normal liver functions
• 2004  – HepaHope tests bio-artificial liver devices
• 2004  – HepaHope builds prototype bio-artificial machine with validation and verification of
  bioreactor unit
• 2005  – FDA IND submission
• 2006  –  Mayo supplies hCD46 transgenic pigs to HepaHope
• 2007  – First generation prototype built for proof for consistency for Chemosensitivity Testing System and BioTester™
• 2008  – HepaHope engages Quintiles Transnational Corp. to manage HepaHope clinical trial in Mexico
• 2009  – License agreement with HepaHope Korea for Chemosensitivity Testing System and BioTester™
• 2009  – Second generation prototype/commercial unit designed and built for
  Chemosensitivity Testing System and BioTester™
• 2009  – Complete the development and assembly of the initial clinical unit of
  HepaPheresis™ System

• Company Overview
• Senior Management
• Science Advisory Board
• History